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High dose vitamin C infusions have become increasingly popular as a complementary treatment for a range of health issues, including cancer, viral infections, and autoimmune diseases. While the benefits of high dose vitamin C are still being studied.

G6PD deficiency and high plasma vitamin C levels can also be a concern during high dose vitamin C infusions. Plasma vitamin C levels can vary widely among individuals, and it is important to monitor these levels during treatment to ensure that they do not become too high. In a study published in the journal Nutrients, researchers found that plasma vitamin C levels increased significantly in individuals receiving high dose vitamin C infusions, and that these levels remained elevated for up to 24 hours after treatment. The authors recommended monitoring plasma vitamin C levels during treatment and adjusting the dose accordingly to avoid potential adverse effects. (2)

Despite these risks, high dose vitamin C infusions have been shown to have potential benefits for the immune system. Vitamin C is an antioxidant that can help protect cells from oxidative damage, and it also plays a role in the production of white blood cells, which are important for fighting infections. In a study published in the journal Nutrients, researchers found that high dose vitamin C infusions improved immune function in critically ill patients, leading the authors to conclude that “vitamin C infusion may be an effective adjuvant therapy in critically ill patients with infection or inflammation.” (3)

It is important to note that high dose vitamin C infusions should not be used as a substitute for conventional medical treatments, and individuals considering this treatment should consult with a healthcare professional before beginning treatment. In addition, individuals with G6PD deficiency or high plasma vitamin C levels should be monitored closely during treatment to ensure that they do not experience adverse effects.

In conclusion, high dose vitamin C infusions have potential benefits for the immune system, but there are also risks associated with this treatment, particularly for individuals with G6PD deficiency or high plasma vitamin C levels. It is important to monitor these levels during treatment and to use caution when administering high doses of vitamin C. While more research is needed to fully understand the benefits and risks of high dose vitamin C infusions, it is clear that this treatment should be used with caution and under the guidance of a healthcare professional.

Sources:

1. Elango S, Periasamy S, Dhanapal P, Padmanaban K, Balasubramanian P, et al. (2018) High Dose Vitamin C Infusion Associated Acute Hemolysis in G6PD Deficiency: A Prospective Bedside Cohort Study. Antioxidants 7(7): 96. doi: 10.3390/antiox7070096
2. Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, Vitamin C and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017