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Whole blood histamine, zinc and copper testing related to depression & anxiety?

Dr. William Walsh developed a unique method for addressing depression that involves monitoring whole blood histamine, kryptopyrroles, zinc and copper, under and over methylation. This approach aims to identify the root cause of depression and anxiety symptoms, allowing for targeted treatment that can have fewer side effects than conventional approaches. Here are the key points of this approach:

  1. Whole Blood Histamine:
  • Low levels of histamine have been linked to depression, anxiety, and other mood disorders.
  • Supplementing folate or histidine, an amino acid that is a precursor to histamine, can help raise histamine levels in the body.
  • Studies show that histidine supplementation can improve symptoms of depression and anxiety (Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805682/)
  • Histamine levels can be monitored using a simple blood test.
  • Patients who have low histamine will often feel worse on SSRI medication while patients with elevated whole blood histamine will feel better on medications that regulate serotonin.
  • Elevated histamine will often cause anxiety.
  1. Kryptopyrroles:
  • Elevated levels of kryptopyrroles, a byproduct of hemoglobin synthesis, have been linked to depression, autism and other mood disorders.
  • Supplementing with zinc and vitamin B6 can help lower kryptopyrrole levels in the body.
  • Studies show that zinc and vitamin B6 supplementation can improve symptoms of depression and anxiety (Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291012/)
  • Kryptopyrrole levels can be monitored using a simple urine test.
  1. Zinc and Copper:
  • Imbalances in zinc and copper levels have been linked to depression and other mood disorders.
  • Supplementing with zinc and avoiding copper-rich foods can help restore balance to these minerals in the body.
  • Studies show that zinc supplementation can improve symptoms of depression and anxiety (Source: https://pubmed.ncbi.nlm.nih.gov/30432796/)
  • Zinc and copper levels can be monitored using a simple test looking at plasma levels.
  1. Under and Over Methylation:
  • Methylation is a process that helps regulate gene expression and neurotransmitter activity in the brain.
  • Both under and over methylation have been linked to depression and other mood disorders.
  • Supplementing with specific vitamins and nutrients, such as SAMe and folic acid, can help regulate methylation levels in the body.
  • Studies show that SAMe supplementation can improve symptoms of depression and anxiety (Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415362/)
  • Methylation status can be monitored using a simple blood test monitoring whole blood histamine.

Overall, Dr. Walsh’s approach to addressing depression and anxiety through targeted nutrient supplementation has shown promising results. By identifying and addressing specific nutrient imbalances in the body, this approach can lead to fewer side effects than conventional antidepressant medications. However, it’s important to note that this approach may not work for everyone, and that individuals should work with a healthcare practitioner to determine the best course of treatment for their specific needs.

Meet the Author

Dr. Matz DC

Dr. Jeffrey E. Matz, DC, MS, is a Board Certified Chiropractic Physician. He is licensed to practice in SC, NC, and GA. Dr. Matz is passionate about functional medicine and strives to help patients achieve optimal health. His focus is on helping our members with hormone imbalances, autoimmune conditions, chronic pain conditions, and diabetes. Among the thousands of people Dr. Matz has treated include Carolina Panthers football players, PGA Tour and Champions Tour golfers, collegiate athletes, and local and international celebrities. Dr. Matz was a semiprofessional cyclist, and has competed in triathlons for the last 7 years, including completing an IRONMAN triathlon.

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