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Research on Low Dose Naltrexone and Crohn’s disease



Low dose naltrexone (LDN) has emerged as a promising alternative treatment for individuals with inflammatory bowel diseases (IBD), such as Crohn’s disease. LDN is a medication that is typically used for the treatment of opioid addiction, but it has also shown positive results in reducing symptoms and improving quality of life in individuals with IBD.

Research studies have found that LDN has the ability to reduce inflammation and improve immune function in individuals with IBD. A study published in the Journal of Clinical Gastroenterology found that LDN was effective in reducing symptoms of abdominal pain, diarrhea, and rectal bleeding in individuals with Crohn’s disease. Another study published in the Journal of Crohn’s and Colitis found that LDN improved overall quality of life and reduced the need for steroid therapy in individuals with IBD.

LDN works by binding to specific receptors in the body, blocking the effects of certain neurotransmitters and modulating the immune system. This modulation of the immune system can help to reduce inflammation and oxidative stress, which are key factors in the development and progression of IBD. Additionally, LDN has been found to improve the gut microbiome, which is essential for overall gut health and immune function.

LDN is considered a safer alternative to biologic therapies, which are often used to treat IBD but have a number of potential side effects. Biologic therapies can increase the risk of infections, cancer, and other serious health problems. In contrast, LDN is considered a safe and well-tolerated treatment for IBD, with few side effects. The most common side effect is mild sleep disturbances, which typically resolve on their own after a few days of treatment.

In conclusion, low dose naltrexone is a promising alternative treatment for individuals with inflammatory bowel diseases, such as Crohn’s disease. The research studies have found that LDN can reduce symptoms, improve quality of life, and modulate the immune system, leading to a reduction in inflammation and oxidative stress. If you are considering LDN for the treatment of your IBD, it is important to work closely with a healthcare provider to determine if it is right for you, and to monitor your symptoms and response to treatment. Compared to biologic alternatives, LDN is considered a safer and well-tolerated option, with fewer potential side effects.

Meet the Author

Dr. Matz DC

Dr. Jeffrey E. Matz, DC, MS, is a Board Certified Chiropractic Physician. He is licensed to practice in SC, NC, and GA. Dr. Matz is passionate about functional medicine and strives to help patients achieve optimal health. His focus is on helping our members with hormone imbalances, autoimmune conditions, chronic pain conditions, and diabetes. Among the thousands of people Dr. Matz has treated include Carolina Panthers football players, PGA Tour and Champions Tour golfers, collegiate athletes, and local and international celebrities. Dr. Matz was a semiprofessional cyclist, and has competed in triathlons for the last 7 years, including completing an IRONMAN triathlon.

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